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KMID : 0624620080410120863
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BMB Reports
2008 Volume.41 No. 12 p.863 ~ p.867
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Expression of CD320 in human B cells in addition to follicular dendritic cells
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Cho Wha-Jung
Choi Jin-Suk
Park Chan-Hum
Yoon Sun-Ok
Jeoung Doo-Il
Kim Young-Myeong
Choe Jong-Seon
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Abstract
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CD320 has been recently discovered and reported as a follicular dendritic cell (FDC) protein. Although CD320 is known to enhance proliferation of germinal center (GC) B cells, little other information is available. In this study, we investigated its cellular distribution in the GC. Confocal microscopy of human tonsil sections revealed co-localization of CD320 with CD19 and CD38 but not with CD3 indicating that GC B cells expressed CD320 in addition to FDC. In purified GC B cells, CD320 expression was inhibited in the nucleus, membrane and cytoplasm. Reverse transcriptase-polymerase chain reaction confirmed CD320 mRNA expression in B cells. These finding indicate that CD320 is expressed in B cells in addition to FDC, and that its GC activity may be more complicated than previously thought.
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KEYWORD
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B Cells, CD320, Germinal center, Human
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